The rapid emergence of extensively drug resistant tuberculosis (XDR-TB) strains highlights the urgent necessity of finding new classes of drugs to kill Mycobacterium tuberculosis with new mechanisms of action. The scarcity of new TB drugs discovered during the last few decades reflects our limited knowledge of essential metabolic processes in M. tuberculosis outside the repertoire of known targets. In this study, small molecules as siderophore inhibitors represent a potential new class of M. tuberculosis inhibitors. Several of the compounds synthesised were found active with compound 10p emerging as a lead for further development.
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